The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment.
Sato T, Gotoh N, Expert Opin Ther Targets, 2009 Jun - link
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.
Gotoh N, Cancer Sci, 2008 Jul - link
Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.
Huang L, Watanabe M, Chikamori M, Kido Y, Yamamoto T, Shibuya M, Gotoh N, Tsuchida N, Oncogene, 2006 Oct 19 - link
The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.
Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, Nakazato H, Shibuya M, Lax I, Lacy E, Schlessinger J, Mol Cell Biol, 2005 May - link
FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.
Gotoh N, Laks S, Nakashima M, Lax I, Schlessinger J, FEBS Lett, 2004 Apr 23 - link
Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways.
Hadari YR, Gotoh N, Kouhara H, Lax I, Schlessinger J, Proc Natl Acad Sci U S A, 2001 Jul 17 - link
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.
Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I, Proc Natl Acad Sci U S A, 2001 May 22 - link