Inverting the enantioselectivity of a carbonyl reductase via substrate-enzyme docking-guided point mutation.
Zhu D, Yang Y, Majkowicz S, Pan TH, Kantardjieff K, Hua L, Org Lett, 2008 Feb 21 - link

Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies.
Zhu D, Yang Y, Buynak JD, Hua L, Org Biomol Chem, 2006 Jul 21 - link