New general approach for determining the solution structure of a ligand bound weakly to a receptor: structure of a fibrinogen Aalpha-like peptide bound to thrombin (S195A) obtained using NOE distance constraints and an ECEPP/3 flexible docking program.
Maurer MC, Trosset JY, Lester CC, DiBella EE, Scheraga HA, Proteins, 1999 Jan 1 - link