Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, Smith U, Proc Natl Acad Sci U S A, 1997 Apr 15 - link